The U225 intradermal injection device is widely used in Israeli clinics. It delivers safe, precise and effective treatments.
Indications include:
1. PRP/PRGF/CGF/PRF injection into the scalp, face or body.
2. Treatment of fine lines and wrinkles, including delicate areas around the eyes and lip lines.
3. Treatment of cellulite and localized fat.
Manual injection control
High injection frequency for rapid, uniform coverage
Precision: injection depth is adjustable from 1 to 10 mm
Ultra-fine needle to minimize pain
Improved patient satisfaction
The U225 is an electro-pneumatic device, air-driven rather than motorized. Both the extrusion pressure that delivers the product and the pressure that drives needle penetration are powered by compressed air. This approach significantly reduces pain and skin trauma while improving results.<br>The compressed air is supplied by a dedicated, portable compressor. The compressor is light and compact, operating quietly and reliably.
The U225 is barely felt during treatment and significantly reduces needle-puncture trauma and bruising
Improves treatment outcomes and enhances ergonomic comfort for the practitioner
Performing a large number of pain-free punctures leads to a significant improvement in treatment outcomes, including the treatment of scars, hair thinning and fine lines.












The U225, manufactured by Needle Concept of France and distributed in Israel by Lee Daniels, is a mesotherapy gun (Mesogun) built on electro-pneumatic technology — injection powered by controlled compressed air, air-driven rather than motorized. Unlike manual injection, where depth and product volume vary from puncture to puncture, the U225 delivers a series of uniform micro-injections — each at an identical depth and dose.
Three parameters can be precisely controlled by the practitioner:
Using compressed air for both needle penetration and product delivery reduces skin trauma and the sensation of pain, producing a consistent, reproducible result from treatment to treatment and from practitioner to practitioner.
What is the U225 used for?
The U225 is a mesotherapy gun (Mesogun) for intradermal injections. It is suited to mesotherapy, PRP/PRF injections and hair, face and body treatments, and is also used for polynucleotide protocols — via precise micro-injections at controlled depth and dose.
What is the difference between manual injection and a mesogun?
With manual injection, needle depth and product volume vary from puncture to puncture and depend on the practitioner’s skill. With the U225 mesogun, every micro-injection is performed at a fixed depth and dose and at a rapid pace, improving the uniformity of the result and reducing pain and skin trauma.
At what depth can you inject with the U225?
The injection depth can be adjusted from 1 to 10 mm, depending on the treatment area and the type of product being injected.